Evidence-Based Clinical Guide: Presentations • Diagnosis • Treatment • Prevention • Pearls
Dosing: 500 mg IM single dose (1 g if ≥150 kg)
Use: First-line for gonorrhea
Note: Can be given IV or IM
Dosing: 800 mg PO single dose
Use: Alternative for gonorrhea when ceftriaxone unavailable
Note: Less effective for pharyngeal gonorrhea
Dosing: 100 mg PO BID × 7 days (chlamydia), × 14 days (early syphilis), × 28 days (late latent syphilis)
Use: First-line for chlamydia, alternative for syphilis
Contraindications: Pregnancy, children <8 years
Dosing: 1 g PO single dose (chlamydia in pregnancy)
Use: Alternative for chlamydia, NOT recommended for gonorrhea
Note: Increasing resistance, less preferred
Dosing: 2.4 million units IM × 1 (early syphilis), × 3 weekly (late syphilis)
Use: ONLY treatment for syphilis in pregnancy
Note: Only effective for preventing congenital syphilis
Dosing: 400 mg PO TID × 7-10 days (first episode), 400 mg PO BID (suppression)
Use: HSV treatment and suppression
Dosing: 1 g PO BID × 7-10 days (first episode), 500 mg-1 g daily (suppression)
Use: HSV treatment, preferred for suppression
Dosing: 250 mg PO TID × 7-10 days (first episode), 250 mg PO BID (suppression)
Use: Alternative for HSV
Dosing: 1 tablet PO daily
Use: Preferred first-line ART
Note: Single tablet regimen
Dosing: 1 tablet PO daily
Use: 2-drug regimen for treatment-naive patients